Zinc(II)-The Overlooked Éminence Grise of Chloroquine's Fight against COVID-19?
Identifieur interne : 000959 ( Main/Exploration ); précédent : 000958; suivant : 000960Zinc(II)-The Overlooked Éminence Grise of Chloroquine's Fight against COVID-19?
Auteurs : Aleksandra Hecel [Pologne] ; Małgorzata Ostrowska [Pologne] ; Kamila Stokowa-Sołtys [Pologne] ; Joanna W Tły [Pologne] ; Dorota Dudek [Pologne] ; Adriana Miller [Pologne] ; Sławomir Potocki [Pologne] ; Agnieszka Matera-Witkiewicz [Pologne] ; Alicia Dominguez-Martin [Espagne] ; Henryk Kozłowski [Pologne] ; Magdalena Rowi Ska- Yrek [Pologne]Source :
- Pharmaceuticals (Basel, Switzerland) [ 1424-8247 ] ; 2020.
Abstract
Zn(II) is an inhibitor of SARS-CoV-2's RNA-dependent RNA polymerase, and chloroquine and hydroxychloroquine are Zn(II) ionophores-this statement gives a curious mind a lot to think about. We show results of the first clinical trials on chloroquine (CQ) and hydroxychloroquine (HCQ) in the treatment of COVID-19, as well as earlier reports on the anticoronaviral properties of these two compounds and of Zn(II) itself. Other FDA-approved Zn(II) ionophores are given a decent amount of attention and are thought of as possible COVID-19 therapeutics.
DOI: 10.3390/ph13090228
PubMed: 32882888
PubMed Central: PMC7558363
Affiliations:
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Joliot-Curie 14, 50-383 Wroclaw, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Faculty of Chemistry, University of Wroclaw, F. 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Joliot-Curie 14, 50-383 Wroclaw, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Faculty of Chemistry, University of Wroclaw, F. Joliot-Curie 14, 50-383 Wroclaw</wicri:regionArea><wicri:noRegion>50-383 Wroclaw</wicri:noRegion></affiliation></author><author><name sortKey="Ostrowska, Malgorzata" sort="Ostrowska, Malgorzata" uniqKey="Ostrowska M" first="Małgorzata" last="Ostrowska">Małgorzata Ostrowska</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Chemistry, University of Wroclaw, F. Joliot-Curie 14, 50-383 Wroclaw, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Faculty of Chemistry, University of Wroclaw, F. Joliot-Curie 14, 50-383 Wroclaw</wicri:regionArea><wicri:noRegion>50-383 Wroclaw</wicri:noRegion></affiliation></author><author><name sortKey="Stokowa Soltys, Kamila" sort="Stokowa Soltys, Kamila" uniqKey="Stokowa Soltys K" first="Kamila" last="Stokowa-Sołtys">Kamila Stokowa-Sołtys</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Chemistry, University of Wroclaw, F. Joliot-Curie 14, 50-383 Wroclaw, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Faculty of Chemistry, University of Wroclaw, F. Joliot-Curie 14, 50-383 Wroclaw</wicri:regionArea><wicri:noRegion>50-383 Wroclaw</wicri:noRegion></affiliation></author><author><name sortKey="W Tly, Joanna" sort="W Tly, Joanna" uniqKey="W Tly J" first="Joanna" last="W Tły">Joanna W Tły</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Chemistry, University of Wroclaw, F. Joliot-Curie 14, 50-383 Wroclaw, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Faculty of Chemistry, University of Wroclaw, F. Joliot-Curie 14, 50-383 Wroclaw</wicri:regionArea><wicri:noRegion>50-383 Wroclaw</wicri:noRegion></affiliation></author><author><name sortKey="Dudek, Dorota" sort="Dudek, Dorota" uniqKey="Dudek D" first="Dorota" last="Dudek">Dorota Dudek</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Chemistry, University of Wroclaw, F. Joliot-Curie 14, 50-383 Wroclaw, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Faculty of Chemistry, University of Wroclaw, F. Joliot-Curie 14, 50-383 Wroclaw</wicri:regionArea><wicri:noRegion>50-383 Wroclaw</wicri:noRegion></affiliation></author><author><name sortKey="Miller, Adriana" sort="Miller, Adriana" uniqKey="Miller A" first="Adriana" last="Miller">Adriana Miller</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Chemistry, University of Wroclaw, F. Joliot-Curie 14, 50-383 Wroclaw, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Faculty of Chemistry, University of Wroclaw, F. Joliot-Curie 14, 50-383 Wroclaw</wicri:regionArea><wicri:noRegion>50-383 Wroclaw</wicri:noRegion></affiliation></author><author><name sortKey="Potocki, Slawomir" sort="Potocki, Slawomir" uniqKey="Potocki S" first="Sławomir" last="Potocki">Sławomir Potocki</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Chemistry, University of Wroclaw, F. Joliot-Curie 14, 50-383 Wroclaw, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Faculty of Chemistry, University of Wroclaw, F. Joliot-Curie 14, 50-383 Wroclaw</wicri:regionArea><wicri:noRegion>50-383 Wroclaw</wicri:noRegion></affiliation></author><author><name sortKey="Matera Witkiewicz, Agnieszka" sort="Matera Witkiewicz, Agnieszka" uniqKey="Matera Witkiewicz A" first="Agnieszka" last="Matera-Witkiewicz">Agnieszka Matera-Witkiewicz</name><affiliation wicri:level="1"><nlm:affiliation>Screening Laboratory of Biological Activity Tests and Collection of Biological Material, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211A, 50-556 Wroclaw, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Screening Laboratory of Biological Activity Tests and Collection of Biological Material, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211A, 50-556 Wroclaw</wicri:regionArea><wicri:noRegion>50-556 Wroclaw</wicri:noRegion></affiliation></author><author><name sortKey="Dominguez Martin, Alicia" sort="Dominguez Martin, Alicia" uniqKey="Dominguez Martin A" first="Alicia" last="Dominguez-Martin">Alicia Dominguez-Martin</name><affiliation wicri:level="4"><nlm:affiliation>Department of Inorganic Chemistry, Faculty of Pharmacy, University of Granada, E-18071 Granada, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Inorganic Chemistry, Faculty of Pharmacy, University of Granada, E-18071 Granada</wicri:regionArea><placeName><region nuts="2" type="communauté">Andalousie</region><settlement type="city">Grenade (Espagne)</settlement></placeName><orgName type="university">Université de Grenade</orgName></affiliation></author><author><name sortKey="Kozlowski, Henryk" sort="Kozlowski, Henryk" uniqKey="Kozlowski H" first="Henryk" last="Kozłowski">Henryk Kozłowski</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Chemistry, University of Wroclaw, F. Joliot-Curie 14, 50-383 Wroclaw, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Faculty of Chemistry, University of Wroclaw, F. Joliot-Curie 14, 50-383 Wroclaw</wicri:regionArea><wicri:noRegion>50-383 Wroclaw</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Physiotherapy, Opole Medical School, Katowicka 68, 40-060 Opole, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Physiotherapy, Opole Medical School, Katowicka 68, 40-060 Opole</wicri:regionArea><wicri:noRegion>40-060 Opole</wicri:noRegion></affiliation></author><author><name sortKey="Rowi Ska Yrek, Magdalena" sort="Rowi Ska Yrek, Magdalena" uniqKey="Rowi Ska Yrek M" first="Magdalena" last="Rowi Ska- Yrek">Magdalena Rowi Ska- Yrek</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Chemistry, University of Wroclaw, F. Joliot-Curie 14, 50-383 Wroclaw, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Faculty of Chemistry, University of Wroclaw, F. Joliot-Curie 14, 50-383 Wroclaw</wicri:regionArea><wicri:noRegion>50-383 Wroclaw</wicri:noRegion></affiliation></author></analytic><series><title level="j">Pharmaceuticals (Basel, Switzerland)</title><idno type="ISSN">1424-8247</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Zn(II) is an inhibitor of <i>SARS-CoV-2</i>'s RNA-dependent RNA polymerase, and chloroquine and hydroxychloroquine are Zn(II) ionophores-this statement gives a curious mind a lot to think about. We show results of the first clinical trials on chloroquine (CQ) and hydroxychloroquine (HCQ) in the treatment of COVID-19, as well as earlier reports on the anticoronaviral properties of these two compounds and of Zn(II) itself. Other FDA-approved Zn(II) ionophores are given a decent amount of attention and are thought of as possible COVID-19 therapeutics.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">32882888</PMID><DateRevised><Year>2020</Year><Month>10</Month><Day>23</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Print">1424-8247</ISSN><JournalIssue CitedMedium="Print"><Volume>13</Volume><Issue>9</Issue><PubDate><Year>2020</Year><Month>Sep</Month><Day>01</Day></PubDate></JournalIssue><Title>Pharmaceuticals (Basel, Switzerland)</Title><ISOAbbreviation>Pharmaceuticals (Basel)</ISOAbbreviation></Journal><ArticleTitle>Zinc(II)-The Overlooked Éminence Grise of Chloroquine's Fight against COVID-19?</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">E228</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.3390/ph13090228</ELocationID><Abstract><AbstractText>Zn(II) is an inhibitor of <i>SARS-CoV-2</i>'s RNA-dependent RNA polymerase, and chloroquine and hydroxychloroquine are Zn(II) ionophores-this statement gives a curious mind a lot to think about. We show results of the first clinical trials on chloroquine (CQ) and hydroxychloroquine (HCQ) in the treatment of COVID-19, as well as earlier reports on the anticoronaviral properties of these two compounds and of Zn(II) itself. Other FDA-approved Zn(II) ionophores are given a decent amount of attention and are thought of as possible COVID-19 therapeutics.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hecel</LastName><ForeName>Aleksandra</ForeName><Initials>A</Initials><Identifier Source="ORCID">0000-0002-4314-9599</Identifier><AffiliationInfo><Affiliation>Faculty of Chemistry, University of Wroclaw, F. Joliot-Curie 14, 50-383 Wroclaw, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ostrowska</LastName><ForeName>Małgorzata</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Faculty of Chemistry, University of Wroclaw, F. Joliot-Curie 14, 50-383 Wroclaw, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stokowa-Sołtys</LastName><ForeName>Kamila</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Faculty of Chemistry, University of Wroclaw, F. Joliot-Curie 14, 50-383 Wroclaw, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wątły</LastName><ForeName>Joanna</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Faculty of Chemistry, University of Wroclaw, F. Joliot-Curie 14, 50-383 Wroclaw, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dudek</LastName><ForeName>Dorota</ForeName><Initials>D</Initials><Identifier Source="ORCID">0000-0002-4699-7665</Identifier><AffiliationInfo><Affiliation>Faculty of Chemistry, University of Wroclaw, F. Joliot-Curie 14, 50-383 Wroclaw, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Miller</LastName><ForeName>Adriana</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Faculty of Chemistry, University of Wroclaw, F. Joliot-Curie 14, 50-383 Wroclaw, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Potocki</LastName><ForeName>Sławomir</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Faculty of Chemistry, University of Wroclaw, F. Joliot-Curie 14, 50-383 Wroclaw, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Matera-Witkiewicz</LastName><ForeName>Agnieszka</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Screening Laboratory of Biological Activity Tests and Collection of Biological Material, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211A, 50-556 Wroclaw, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dominguez-Martin</LastName><ForeName>Alicia</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Inorganic Chemistry, Faculty of Pharmacy, University of Granada, E-18071 Granada, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kozłowski</LastName><ForeName>Henryk</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Faculty of Chemistry, University of Wroclaw, F. Joliot-Curie 14, 50-383 Wroclaw, Poland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Physiotherapy, Opole Medical School, Katowicka 68, 40-060 Opole, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rowińska-Żyrek</LastName><ForeName>Magdalena</ForeName><Initials>M</Initials><Identifier Source="ORCID">0000-0002-0425-1128</Identifier><AffiliationInfo><Affiliation>Faculty of Chemistry, University of Wroclaw, F. Joliot-Curie 14, 50-383 Wroclaw, Poland.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>UMO-2017/26/A/ST5/00363</GrantID><Agency>Narodowe Centrum Nauki</Agency><Country></Country></Grant><Grant><GrantID>UMO-2017/26/A/ST5/00364</GrantID><Agency>Narodowe Centrum Nauki</Agency><Country></Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>09</Month><Day>01</Day></ArticleDate></Article><MedlineJournalInfo><Country>Switzerland</Country><MedlineTA>Pharmaceuticals (Basel)</MedlineTA><NlmUniqueID>101238453</NlmUniqueID><ISSNLinking>1424-8247</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">2019-nCoV</Keyword><Keyword MajorTopicYN="N">COVID-19</Keyword><Keyword 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name="Pologne"><noRegion><name sortKey="Hecel, Aleksandra" sort="Hecel, Aleksandra" uniqKey="Hecel A" first="Aleksandra" last="Hecel">Aleksandra Hecel</name></noRegion><name sortKey="Dudek, Dorota" sort="Dudek, Dorota" uniqKey="Dudek D" first="Dorota" last="Dudek">Dorota Dudek</name><name sortKey="Kozlowski, Henryk" sort="Kozlowski, Henryk" uniqKey="Kozlowski H" first="Henryk" last="Kozłowski">Henryk Kozłowski</name><name sortKey="Kozlowski, Henryk" sort="Kozlowski, Henryk" uniqKey="Kozlowski H" first="Henryk" last="Kozłowski">Henryk Kozłowski</name><name sortKey="Matera Witkiewicz, Agnieszka" sort="Matera Witkiewicz, Agnieszka" uniqKey="Matera Witkiewicz A" first="Agnieszka" last="Matera-Witkiewicz">Agnieszka Matera-Witkiewicz</name><name sortKey="Miller, Adriana" sort="Miller, Adriana" uniqKey="Miller A" first="Adriana" last="Miller">Adriana Miller</name><name sortKey="Ostrowska, Malgorzata" sort="Ostrowska, Malgorzata" uniqKey="Ostrowska M" first="Małgorzata" last="Ostrowska">Małgorzata Ostrowska</name><name sortKey="Potocki, Slawomir" sort="Potocki, Slawomir" uniqKey="Potocki S" first="Sławomir" last="Potocki">Sławomir Potocki</name><name sortKey="Rowi Ska Yrek, Magdalena" sort="Rowi Ska Yrek, Magdalena" uniqKey="Rowi Ska Yrek M" first="Magdalena" last="Rowi Ska- Yrek">Magdalena Rowi Ska- Yrek</name><name sortKey="Stokowa Soltys, Kamila" sort="Stokowa Soltys, Kamila" uniqKey="Stokowa Soltys K" first="Kamila" last="Stokowa-Sołtys">Kamila Stokowa-Sołtys</name><name sortKey="W Tly, Joanna" sort="W Tly, Joanna" uniqKey="W Tly J" first="Joanna" last="W Tły">Joanna W Tły</name></country><country name="Espagne"><region name="Andalousie"><name sortKey="Dominguez Martin, Alicia" sort="Dominguez Martin, Alicia" uniqKey="Dominguez Martin A" first="Alicia" last="Dominguez-Martin">Alicia Dominguez-Martin</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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